Functionalized bicyclic amino-azaheterocycles are rapidly accessed in a one-pot cross-coupling/reduction sequence enabled by the use of COware. Incompatible reagents are physically separated in a single reaction vessel to effect two chemoselective transformations—Suzuki–Miyaura cross-coupling and heteroarene reduction. The developed method allows access to novel heterocyclic templates, including semisaturated Hedgehog and dual PI3K/mTOR inhibitors, which show enhanced physicochemical properties compared to their unsaturated counterparts.

中文翻译：

---

COware实现的功能化氨基氮杂环杂环化合物的化学选择性一锅合成

功能化的双环氨基氮杂环化合物可以通过使用COware实现的一锅式交叉偶联/还原序列快速访问。不相容的试剂在一个反应​​容器中进行物理分离，以实现两个化学选择性转化-Suzuki-Miyaura交叉偶联和杂芳烃还原。所开发的方法允许访问新型杂环模板，包括半饱和刺猬和双PI3K / mTOR抑制剂，与不饱和对应物相比，它们显示出增强的理化性质。