DNA-Decorated Two-Dimensional Crystalline Nanosheets,Journal of the American Chemical Society

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DNA-Decorated Two-Dimensional Crystalline Nanosheets
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2017-11-14 , DOI: 10.1021/jacs.7b09283
Shine K. Albert ₁ , Irla Sivakumar ₁ , Murali Golla ₁ , Hari Veera Prasad Thelu ₁ , Nithiyanandan Krishnan ₁ , Joseph Libin K. L. ₁ , Ashish ₂ , Reji Varghese ₁

Affiliation

Design and synthesis of high aspect ratio 2D nanosheets with surface having ultradense array of information-rich molecule such as DNA is extremely challenging. Herein, we report a universal strategy based on amphiphilicity-driven self-assembly for the crafting of high aspect ratio, 2D sheets that are densely surface-decorated with DNA. Microscopy and X-ray analyses have shown that the sheets are crystalline. The most unique feature of the sheets is DNA-directed surface addressability, which is demonstrated through the decoration of either faces of the sheet with gold nanoparticles through sequence-specific DNA hybridization. Our results suggest that this design strategy can be applied as a general approach for the synthesis of DNA decorated high aspect ratio sheets, which may find potential applications in materials science, drug delivery, and nanoelectronics.

中文翻译：

DNA装饰的二维晶体纳米片

设计和合成表面具有超密集信息丰富分子（如 DNA）阵列的高纵横比 2D 纳米片极具挑战性。在此，我们报告了一种基于两亲性驱动的自组装的通用策略，用于制作高纵横比、表面有 DNA 密集装饰的 2D 片材。显微镜和 X 射线分析表明，这些薄片是结晶的。薄片最独特的特征是 DNA 导向的表面可寻址性，这可以通过序列特异性 DNA 杂交用金纳米粒子装饰薄片的任一面来证明。我们的结果表明，这种设计策略可以作为合成 DNA 装饰高纵横比片的通用方法，这可能会在材料科学、药物输送、

更新日期：2017-11-14

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