Benzisoxazole: a privileged scaffold for medicinal chemistry,RSC Medicinal Chemistry

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Benzisoxazole: a privileged scaffold for medicinal chemistry
RSC Medicinal Chemistry ( IF 4.1 ) Pub Date : 2017-10-31 00:00:00 , DOI: 10.1039/c7md00449d
K. P. Rakesh _{1,

2,

3,

4,

5} , C. S. Shantharam _{6,

7,

8,

9} , M. B. Sridhara _{6,

9,

10,

11} , H. M. Manukumar _{9,

12,

13,

14} , Hua-Li Qin _{1,

2,

3,

4,

5}

Affiliation

The benzisoxazole analogs represent one of the privileged structures in medicinal chemistry and there has been an increasing number of studies on benzisoxazole-containing compounds. The unique benzisoxazole scaffold also exhibits an impressive potential as antimicrobial, anticancer, anti-inflammatory, anti-glycation agents and so on. This review examines the state of the art in medicinal chemistry as it relates to the comprehensive and general summary of the different benzisoxazole analogs, their use as starting building blocks of multifarious architectures on scales sufficient to drive human drug trials. The number of reports describing benzisoxazole-containing highly active compounds leads to the expectation that this scaffold will further emerge as a potential candidate in the field of drug discovery.

中文翻译：

苯并异恶唑：一种用于药物化学的特有支架

苯并异恶唑类似物代表药物化学中的优先结构之一，并且对含苯并异恶唑化合物的研究越来越多。独特的苯并异恶唑支架还具有令人印象深刻的潜力，如抗菌剂，抗癌剂，抗炎剂，抗糖化剂等。这篇综述探讨了药物化学领域的最新情况，因为它涉及到不同的苯并异恶唑类似物的全面概括，涉及它们在足以推动人类药物试验的规模上作为多种结构的基础。描述含苯并异恶唑的高活性化合物的大量报告导致人们期望这种支架将进一步成为药物发现领域的潜在候选者。

更新日期：2017-11-16

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