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1,3-Dibromo-5,5-dimethylhydantoin mediated oxidative amidation of terminal alkenes in water
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2017-11-09 00:00:00 , DOI: 10.1039/c7ob02329d
Chunhua Ma 1, 2, 3, 4, 5 , Guojie Fan 1, 2, 3, 4, 5 , Ping Wu 6, 7, 8, 9 , Zhi Li 6, 7, 8, 9 , Yang Zhou 6, 7, 8, 9 , Qingjie Ding 1, 2, 3, 4, 5 , Wei Zhang 6, 7, 8, 9
Affiliation  

A variety of terminal alkenes were converted to the corresponding amides in yields of 25 to 86% in water via treatment with 1,3-dibromo-5,5-dimethylhydantoin, followed by reaction with molecular iodine and aq. NH3 (or amine) in one pot. This metal- and organic solvent-free protocol is not only suitable for styrene derivatives, but also, for the first time, works well on terminal aliphatic alkenes.

中文翻译:

1,3-二溴-5,5-二甲基乙内酰脲介导的末端烯烃在水中的氧化酰胺化

通过用1,3-二溴-5,5-二甲基乙内酰脲处理,然后与分子碘和HCl水溶液反应,将多种末端烯烃在水中以25-86%的产率转化为相应的酰胺。一锅中加入NH 3(或胺)。这种无金属和有机溶剂的方案不仅适用于苯乙烯衍生物,而且首次在末端脂族烯烃上效果很好。
更新日期:2017-11-16
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