Membrane environment drives cytochrome P450's spin transition and its interaction with cytochrome b5,Chemical Communications

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Membrane environment drives cytochrome P450's spin transition and its interaction with cytochrome b5
Chemical Communications ( IF 4.3 ) Pub Date : 2017-11-10 00:00:00 , DOI: 10.1039/c7cc07520k
Thirupathi Ravula _{1,

2,

3,

4} , Carlo Barnaba _{1,

2,

3,

4} , Mukesh Mahajan _{1,

2,

3,

4} , G. M. Anantharamaiah _{4,

5,

6,

7} , Sang-Choul Im _{3,

4,

8,

9} , Lucy Waskell _{3,

4,

8,

9} , Ayyalusamy Ramamoorthy _{1,

2,

3,

4}

Affiliation

Heme's spin-multiplicity is key in determining the enzymatic function of cytochrome P450 (cytP450). The origin of the low-spin state in ferric P450 is still under debate. Here, we report the first experimental demonstration of P450's membrane interaction altering its spin equilibrium which is accompanied by a stronger affinity for cytochrome b₅. These results highlight the importance of lipid membrane for the function of P450.

中文翻译：

膜环境驱动细胞色素P450的自旋转变及其与细胞色素b _5的相互作用

血红素的自旋多重性是决定细胞色素P450（cytP450）酶功能的关键。P450铁的低旋转状态的起源仍在争论中。在这里，我们报告P450的膜相互作用改变其自旋平衡，并伴随着对细胞色素b ₅的更强亲和力的第一个实验证明。这些结果突出了脂质膜对P450功能的重要性。

更新日期：2017-11-16

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