当前位置: X-MOL 学术Chem. Commun. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Dual-target cancer theranostic for glutathione S-transferase and hypoxia-inducible factor-1α inhibition
Chemical Communications ( IF 4.3 ) Pub Date : 2017-10-30 00:00:00 , DOI: 10.1039/c7cc08162f
Zan Li 1, 2, 3, 4, 5 , Jie Ding 6, 7, 8, 9, 10 , Chunxia Chen 1, 2, 3, 4, 5 , Jiayin Chang 1, 2, 3, 4, 5 , Binghuan Huang 1, 2, 3, 4, 5 , Zhirong Geng 1, 2, 3, 4, 5 , Zhilin Wang 1, 2, 3, 4, 5
Affiliation  

We developed a dual-target theranostic F671, which could exhibit synergetic anticancer effects for inhibiting the activities of glutathione S-transferase and the accumulation of hypoxia inducible factor-1α. F671 undergoes self-immolative cleavage when exposed to GSTP1-1 in live cancer cells, facilitating the visualization of molecule release and distribution, as well as confirming the autophagy-induced apoptosis.

中文翻译:

谷胱甘肽S-转移酶和缺氧诱导因子-1α抑制的双重靶基因治疗

我们开发了一种双靶基因治疗药物F 671,它可以发挥协同抗癌作用,抑制谷胱甘肽S-转移酶的活性和缺氧诱导因子-1α的积累。当暴露于活癌细胞中的GSTP1-1时,F 671会经历自消灭性裂解,从而促进了分子释放和分布的可视化,并证实了自噬诱导的细胞凋亡。
更新日期:2017-11-16
down
wechat
bug