Dual-target cancer theranostic for glutathione S-transferase and hypoxia-inducible factor-1α inhibition,Chemical Communications

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Dual-target cancer theranostic for glutathione S-transferase and hypoxia-inducible factor-1α inhibition
Chemical Communications ( IF 4.3 ) Pub Date : 2017-10-30 00:00:00 , DOI: 10.1039/c7cc08162f
Zan Li _{1,

2,

3,

4,

5} , Jie Ding _{6,

7,

8,

9,

10} , Chunxia Chen _{1,

2,

3,

4,

5} , Jiayin Chang _{1,

2,

3,

4,

5} , Binghuan Huang _{1,

2,

3,

4,

5} , Zhirong Geng _{1,

2,

3,

4,

5} , Zhilin Wang _{1,

2,

3,

4,

5}

Affiliation

We developed a dual-target theranostic F₆₇₁, which could exhibit synergetic anticancer effects for inhibiting the activities of glutathione S-transferase and the accumulation of hypoxia inducible factor-1α. F₆₇₁ undergoes self-immolative cleavage when exposed to GSTP1-1 in live cancer cells, facilitating the visualization of molecule release and distribution, as well as confirming the autophagy-induced apoptosis.

中文翻译：

谷胱甘肽S-转移酶和缺氧诱导因子-1α抑制的双重靶基因治疗

我们开发了一种双靶基因治疗药物F ₆₇₁，它可以发挥协同抗癌作用，抑制谷胱甘肽S-转移酶的活性和缺氧诱导因子-1α的积累。当暴露于活癌细胞中的GSTP1-1时，F ₆₇₁会经历自消灭性裂解，从而促进了分子释放和分布的可视化，并证实了自噬诱导的细胞凋亡。

更新日期：2017-11-16

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