Single-step synthesis of styryl phosphonic acids via palladium-catalyzed Heck coupling of vinyl phosphonic acid with aryl halides,Chemical Communications

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Single-step synthesis of styryl phosphonic acids via palladium-catalyzed Heck coupling of vinyl phosphonic acid with aryl halides
Chemical Communications ( IF 4.3 ) Pub Date : 2017-10-27 00:00:00 , DOI: 10.1039/c7cc05909d
Brett W. McNichols _{1,

1,

2,

3,

4} , Joshua T. Koubek _{1,

2,

3,

4} , Alan Sellinger _{1,

2,

3,

4,

5}

Affiliation

We have developed a single step palladium-catalyzed Heck coupling of aryl halides with vinyl phosphonic acid to produce functionalized (E)-styryl phosphonic acids. This pathway utilizes a variety of commercially available aryl halides, vinyl phosphonic acid and Pd(P(tBu)₃)₂ as catalyst. These conditions produce a wide range of styryl phosphonic acids with high purities and good to excellent yields (31–80%).

中文翻译：

通过钯催化的乙烯基膦酸与芳基卤化物的Heck偶联一步合成苯乙烯基膦酸

我们已经开发了单步钯催化的芳基卤化物与乙烯基膦酸的钯催化Heck偶联，以生产功能化的（E）-苯乙烯基膦酸。该途径利用各种可商购的芳基卤化物，乙烯基膦酸和Pd（P（t Bu）₃）₂作为催化剂。这些条件产生了多种苯乙烯基膦酸，纯度高，收率好至极佳（31–80％）。

更新日期：2017-11-16

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