Organocatalyst-assisted Ar–18F bond formation: a universal procedure for direct aromatic radiofluorination,Chemical Communications

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Organocatalyst-assisted Ar–18F bond formation: a universal procedure for direct aromatic radiofluorination
Chemical Communications ( IF 4.3 ) Pub Date : 2017-10-23 00:00:00 , DOI: 10.1039/c7cc07211b
Jimmy Erik Jakobsson _{1,

2,

3,

4,

5} , Gaute Grønnevik _{1,

2,

3,

4,

5} , Patrick Johannes Riss _{1,

2,

3,

4,

5}

Affiliation

A metal free, phosphane-catalysed protocol for C–F bond formation based on ipso-elimination of iodanes is described. The reaction proceeds in significantly higher yield and with markedly reduced variability of yields (yield range) than previously described procedures. Rapid and efficient radiofluorination is achieved using unobjectionable chemical reagents with precedence in routine radiotracer production. With operational ease and mild conditions, the method promises a high potential for radiolabelling of biomolecules.

中文翻译：

有机催化剂辅助的Ar– ¹⁸ F键形成：直接进行芳族放射性氟化的通用方法

描述了一种基于金属的，碘化的碘催化的膦基催化的C-F键形成方案。与先前描述的方法相比，反应以明显更高的收率进行并且收率的可变性（收率范围）显着降低。使用常规放射性示踪剂生产中优先使用的无害化学试剂可实现快速有效的放射性氟化。由于操作简便且条件温和，该方法有望对生物分子进行放射性标记。

更新日期：2017-11-16

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