Hematopoietic stem cells (HSCs) ensure a balanced production of all blood cells throughout life. As they age, HSCs gradually lose their self-renewal and regenerative potential, whereas the occurrence of cellular derailment strongly increases. Here we review our current understanding of the molecular mechanisms that contribute to HSC aging. We argue that most of the causes that underlie HSC aging result from cell-intrinsic pathways, and reflect on which aspects of the aging process may be reversible. Because many hematological pathologies are strongly age-associated, strategies to intervene in aspects of the stem cell aging process may have significant clinical relevance.

中文翻译：

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造血干细胞老化

造血干细胞 (HSC) 可确保所有血细胞在整个生命过程中的平衡生产。随着年龄的增长，HSC 逐渐失去自我更新和再生的潜力，而细胞脱轨的发生率却大大增加。在这里，我们回顾了我们目前对导致 HSC 衰老的分子机制的理解。我们认为导致 HSC 衰老的大多数原因来自细胞内在途径，并反映了衰老过程的哪些方面可能是可逆的。由于许多血液病理学与年龄密切相关，因此干预干细胞衰老过程的各个方面的策略可能具有重要的临床意义。