Guided by theoretical calculations, we predicted that 5,5,6,6-tetrafluoro-1-methoxycyclohex-1-ene, a new structural motif, exhibits a large negative dielectric anisotropy, and then developed a synthetic strategy for the preparation of the novel tetrafluorinated tricyclic mesogen in twelve reaction steps starting from a commercially available fluorinated starting material. During the evaluation of its liquid-crystalline characteristics, the tetrafluorinated mesogen was found to display low birefringence and a large negative dielectric anisotropy, confirming that its molecular structure is a reasonable design for the further development of novel mesogenic molecules with large negative dielectric anisotropies.

中文翻译：

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具有较大负介电各向异性的新型侧向四氟化三环液晶元的合理设计与合成

在理论计算的指导下，我们预测5,5,6,6-四氟-1-甲氧基环己-1-烯是一种新的结构基序，表现出较大的负介电各向异性，然后开发了合成该新结构的策略。从市售的氟化原料开始的十二个反应步骤中得到四氟化三环液晶元。在评估其液晶特性期间，发现四氟化液晶元显示出低双折射和大的负介电各向异性，从而证实其分子结构是进一步开发具有大的负介电各向异性的新型介晶分子的合理设计。