Access to Chiral Hydropyrimidines through Palladium-Catalyzed Asymmetric Allylic C−H Amination,Angewandte Chemie International Edition

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Access to Chiral Hydropyrimidines through Palladium-Catalyzed Asymmetric Allylic C−H Amination
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2017-11-15 12:31:26 , DOI: 10.1002/anie.201709681
Pu-Sheng Wang ₁ , Meng-Lan Shen ₁ , Tian-Ci Wang ₁ , Hua-Chen Lin ₁ , Liu-Zhu Gong _{1,

2}

Affiliation

Getting to the core of it: An asymmetric palladium-catalyzed intramolecular allylic C−H amination controlled by a chiral phosphoramidite ligand was used to provide efficient access various substituted chiral hydropyrimidines. This methodology was successfully applied to the asymmetric synthesis of letermovir (see scheme; IMDA=intramolecular Diels–Alder reaction).

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