Palladium‐Catalyzed Dehydrogenation of Benzyl Alcohols for Construction of 2‐Arylbenzimidazoles “On Water”,Asian Journal of Organic Chemistry

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Palladium‐Catalyzed Dehydrogenation of Benzyl Alcohols for Construction of 2‐Arylbenzimidazoles “On Water”
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2017-12-21 , DOI: 10.1002/ajoc.201700618
Hidemasa Hikawa ₁ , Risa Ichinose ₁ , Shoko Kikkawa ₁ , Isao Azumaya ₁

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An “on water” synthetic strategy for the selective construction of 2‐arylbenzimidazoles involving the dehydrogenation of benzyl alcohols by a π‐benzylpalladium(II) system has been developed. This simple oxidant‐ and base‐free protocol can be achieved under mild conditions in an atom‐economic process from o‐phenylenediamines and benzyl alcohols, affording the desired products in moderate to excellent yields. Notably, the “on water” protocol is essential for achieving this new synthetic method in our catalytic system.

中文翻译：

用于水上2-芳基苯并咪唑的钯醇催化的苄醇脱氢反应

已开发出一种“水上”合成策略，用于选择性构建2-芳基苯并咪唑，涉及通过π-苄基钯（II）系统对苯甲醇进行脱氢。这种简单的无氧化剂和无碱方案可以在温和的条件下，通过邻苯二胺和苄醇在原子经济过程中完成，从而以中等至极好的收率提供所需的产品。值得注意的是，“水上”方案对于在我们的催化系统中实现这种新的合成方法至关重要。

更新日期：2017-12-21

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