Chemoselective N-arylation of aminobenzamides via copper catalysed Chan–Evans–Lam reactions,Organic & Biomolecular Chemistry

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Chemoselective N-arylation of aminobenzamides via copper catalysed Chan–Evans–Lam reactions
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2017-10-23 00:00:00 , DOI: 10.1039/c7ob02491f
Shuai Liu _{1,

2,

3,

4} , Weisai Zu _{1,

2,

3,

4} , Jinli Zhang _{1,

2,

3,

4,

5} , Liang Xu _{1,

2,

3,

4}

Affiliation

Chemoselective N-arylation of unprotected aminobenzamides was achieved via Cu-catalysed Chan–Evans–Lam cross-coupling with aryl boronic acids for the first time. Simple copper catalysts enable the selective arylation of amino groups in ortho/meta/para-aminobenzamides under open-flask conditions. The reactions were scalable and compatible with a wide range of functional groups.

中文翻译：

化学选择性Ñ氨基苯甲酰胺的-arylation通过铜催化的赞埃文斯-榄反应

未保护的氨基苯甲酰胺的化学选择性N-芳基化是通过Cu催化的Chan-Evans-Lam与芳基硼酸的首次交叉偶联而实现的。简单的铜催化剂可以在开瓶条件下使邻/间/对-氨基苯甲酰胺中的氨基选择性芳基化。反应是可扩展的，并且与多种官能团相容。

更新日期：2017-11-15

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