Design of Glycopolymers Carrying Sialyl Oligosaccharides for Controlling the Interaction with the Influenza Virus,Biomacromolecules

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Design of Glycopolymers Carrying Sialyl Oligosaccharides for Controlling the Interaction with the Influenza Virus
Biomacromolecules ( IF 5.5 ) Pub Date : 2017-11-14 00:00:00 , DOI: 10.1021/acs.biomac.7b01426
Masanori Nagao ₁ , Yurina Fujiwara ₂ , Teruhiko Matsubara ₂ , Yu Hoshino ₁ , Toshinori Sato ₂ , Yoshiko Miura ₁

Affiliation

We designed glycopolymers carrying sialyl oligosaccharides by “post-click” chemistry and evaluated the interaction with the influenza virus. The glycopolymer structures were synthesized in a well-controlled manner by reversible addition–fragmentation chain transfer polymerization and the Huisgen reaction. Acrylamide-type monomers were copolymerized to give hydrophilicity to the polymer backbones, and the hydrophilicity enabled the successful introduction of the oligosaccharides into the polymer backbones. The glycopolymers with different sugar densities and polymer lengths were designed for the interaction with hemagglutinin on the virus surface. The synthesized glycopolymers showed the specific molecular recognition against different types of influenza viruses depending on the sugar units (6′- or 3′-sialyllactose). The sugar density and the polymer length of the glycopolymers affected the interaction with the influenza virus. Inhibitory activity of the glycopolymer against virus infection was demonstrated.

中文翻译：

携带唾液酸低聚糖的糖聚合物控制与流感病毒相互作用的设计

我们通过“点击后”化学方法设计了携带唾液酸寡糖的糖聚合物，并评估了与流感病毒的相互作用。通过可逆的加成-断裂链转移聚合和Huisgen反应，以可控的方式合成了糖聚合物的结构。丙烯酰胺型单体被共聚以赋予聚合物主链亲水性，并且亲水性使得能够将寡糖成功地引入到聚合物主链中。设计具有不同糖密度和聚合物长度的糖聚合物以与病毒表面上的血凝素相互作用。合成的糖聚合物根据糖单元（6'-或3'-唾液乳糖）显示出针对不同类型流感病毒的特异性分子识别。糖聚合物的糖密度和聚合物长度影响与流感病毒的相互作用。证明了糖聚合物对病毒感染的抑制活性。

更新日期：2017-11-15

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