The development of catalytic, enantioselective halofunctionalizations of unactivated alkenes has made significant progress in recent years. However, the identification of generally applicable catalysts for wide range of substrates has yet to be realized. A detailed understanding of the reaction mechanism is essential to guide the formulation of a truly general catalyst. Herein, we present our investigations on the enantiodetermining step of a Lewis base catalyzed bromocycloetherification that provides important insights and design criteria.

中文翻译：

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研究手性路易斯碱催化的特权烯烃溴环醚化的对映决定步骤

近年来，未活化烯烃的催化、对映选择性卤代官能化的发展取得了重大进展。然而，尚未实现对广泛底物的普遍适用催化剂的鉴定。详细了解反应机理对于指导真正通用催化剂的配方至关重要。在此，我们介绍了我们对路易斯碱催化溴环醚化的对映体决定步骤的研究，该步骤提供了重要的见解和设计标准。