Multifunctional core–shell nanostructures formed by integration of distinct components have received wide attention as promising biological platforms inrecent years. In this work, crystalline zeolitic imidazolate framework-8 (ZIF-8), a typical metal-organic framework (MOF), is coated onto single gold nanorod(AuNR) core for successful realization of synergistic photothermal andchemotherapy triggered by near-infrared (NIR) light. Impressively, high doxorubicin hydrochloride (DOX) loading capacity followed by pH and NIR light dual stimuli-responsive DOX release can be easily implemented throughformation and breakage of coordination bonds in the system. Moreover, underNIR laser irradiation at 808 nm, these novel AuNR@MOF core–shell nanostructures exhibit effective synergistic chemo-photothermal therapy both in vitro and in vivo, confirmed by cell treatment and tumor ablation viaintravenous injection.

中文翻译：

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金纳米棒@金属-有机框架核-壳纳米结构内部的配位响应药物释放，用于近红外诱导的协同化学-光热疗法

由不同成分的整合形成的多功能核-壳纳米结构作为近几年有希望的生物平台而受到了广泛的关注。在这项工作中，将典型的金属-有机骨架（MOF）的结晶沸石咪唑酸酯骨架8（ZIF-8）涂覆在单个金纳米棒（AuNR）核上，以成功实现由近红外（NIR）引发的协同光热化学疗法） 光。令人印象深刻的是，通过系统中配位键的形成和破坏，可以轻松实现高阿霉素盐酸盐（DOX）负载能力以及随后的pH和NIR光双刺激响应性DOX释放。此外，在808 nm的近红外激光照射下，这些新颖的AuNR @ MOF核-壳纳米结构在体外均表现出有效的协同化学光热疗法。并且在体内，通过细胞治疗和静脉注射消融证实。