Nanostructured mesoporous silicon (pSi) derived from the silicon-accumulator plant Tabasheer (Bambuseae) is demonstrated to serve as a potential carrier matrix for carrying and stabilizing naturally active, but otherwise metastable, therapeutic agents. Particularly, in this study, garlic oil containing phytochemicals (namely, allicin) that are capable of inhibiting Staphylococcus aureus (S. aureus) bacterial growth were incorporated into Tabasheer-derived porous silicon. Thermogravimetric analysis (TGA) indicated that relatively high amounts of the extract (53.1 ± 2.2 wt %) loaded into pSi are possible by simple infiltration. Furthermore, by assessing the antibacterial activity of the samples using a combination technique of agar disk diffusion and turbidity assays against S. aureus, we report that biogenic porous silicon can be utilized to stabilize and enhance the therapeutic effects of garlic oil for up to 4 weeks when the samples were stored under refrigerated conditions (4 °C) and 1 week at room temperature (25 °C). Critically, under ultraviolet (UV) light (365 nm) irradiation for 24 h intervals, plant-derived pSi is shown to have superior performance in protecting garlic extracts over porous silica (pSiO₂) derived from the same plant feedstock or extract-only controls. The mechanism for this effect has also been investigated.

中文翻译：

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生物纳米结构多孔硅作为载体，用于稳定和递送天然治疗药物。

已证明，来自硅蓄积工厂Tabasheer（Bambuseae）的纳米结构介孔硅（pSi）可作为潜在的载体基质，用于携带和稳定天然活性的治疗药物，但该药物还是亚稳的。特别是，在这项研究中，大蒜油中含有能够抑制金黄色葡萄球菌（金黄色葡萄球菌）的植物化学成分（即大蒜素）。细菌的生长被整合到Tabasheer衍生的多孔硅中。热重分析（TGA）表明，通过简单的渗透，可以将相对大量的提取物（53.1±2.2 wt％）装载到pSi中。此外，通过使用琼脂圆盘扩散和浊度分析的组合技术评估样品的抗菌活性，对金黄色葡萄球菌，我们报告说，当样品在冷藏条件下（4°C）和在室温（25°C）下保存1周时，可利用生物多孔硅来稳定和增强大蒜油的治疗效果长达4周。至关重要的是，在紫外（UV）光（365 nm）照射下间隔24小时，已证明植物来源的pSi在保护大蒜提取物方面优于在相同植物原料或仅提取物对照中得到的多孔二氧化硅（pSiO ₂）。 。还已经研究了这种作用的机理。