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Copper-Catalyzed Enantioselective Synthesis of β-Boron β-Amino Esters
Organic Letters ( IF 4.9 ) Pub Date : 2017-11-13 00:00:00 , DOI: 10.1021/acs.orglett.7b02784
Aurora López , Timothy B. Clark 1 , Alejandro Parra , Mariola Tortosa
Affiliation  

In this report, the enantioselective, copper-catalyzed borylation of β-amidoacrylates is disclosed. A broad variety of biologically important α-aminoboronates has been prepared with consistently high levels of enantiocontrol using an inexpensive copper catalyst and a commercially available chiral ligand. The method can be applied to the synthesis of novel boron-containing dipeptides and hemiboronates.

中文翻译:

铜催化β-硼β-氨基酯的对映选择性合成

在该报告中,公开了β-酰胺基丙烯酸酯的对映选择性的铜催化的硼酸酯化。已经使用廉价的铜催化剂和可商购的手性配体制备了具有一致高水平对映体控制的多种生物学上重要的生物学重要的α-氨基硼酸酯。该方法可用于合成新型的含硼二肽和半硼酸酯。
更新日期:2017-11-13
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