Synthesis of 2,2-bis(pyridin-2-yl amino)cyclobutanols and their conversion into 5-(pyridin-2-ylamino)dihydrofuran-2(3H)-ones,Organic & Biomolecular Chemistry

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Synthesis of 2,2-bis(pyridin-2-yl amino)cyclobutanols and their conversion into 5-(pyridin-2-ylamino)dihydrofuran-2(3H)-ones
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2017-11-08 00:00:00 , DOI: 10.1039/c7ob02567j
Lorenza Ghisu _{1,

2,

3,

4,

5} , Nicola Melis _{1,

2,

3,

4,

5} , Francesco Secci _{1,

2,

3,

4,

5} , Pierluigi Caboni _{2,

4,

5,

6} , Massimiliano Arca _{1,

2,

3,

4,

5} , Régis Guillot _{7,

8,

9,

10,

11} , Thomas Boddaert _{7,

8,

9,

10,

11} , David J. Aitken _{7,

8,

9,

10,

11} , Angelo Frongia _{1,

2,

3,

4,

5}

Affiliation

A two-step protocol is presented for the preparation of 5-(pyridin-2-ylamino)dihydrofuran-2(3H)-ones from 2-hydroxycyclobutanone and some 2-aminopyridines via a catalyst-free synthesis of 2,2-bis(pyridin-2-ylamino)cyclobutanols followed by Dess–Martin periodinane mediated ring expansion.

中文翻译：

2,2-双（吡啶-2-基氨基）环丁醇的合成及其转化为5-（吡啶-2-基氨基）二氢呋喃-2（3 H）-ones

提出了一个两步协议，通过无催化剂合成2,2-双，从2-羟基环丁酮和一些2-氨基吡啶制备5-（吡啶-2-基氨基）二氢呋喃-2（3 H）-酮。（吡啶-2-基氨基）环丁醇，然后由Dess-Martin高碘烷介导的扩环。

更新日期：2017-11-14

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