Palladium‐Catalyzed ortho‐Alkoxylation of Tertiary Benzamides: H2SO4 as an Effective Additive,Asian Journal of Organic Chemistry

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Palladium‐Catalyzed ortho‐Alkoxylation of Tertiary Benzamides: H2SO4 as an Effective Additive
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2017-11-14 , DOI: 10.1002/ajoc.201700525
Fang-Cheng Qiu ₁ , Qi Xie ₁ , Bing-Tao Guan _{1,

2}

Affiliation

Transition metal‐catalyzed C−H bond alkoxylation reactions represent a direct and efficient strategy for the synthesis of aryl ethers. However, the substrate scope of these methods has been greatly limited so far. Herein, we report a palladium‐catalyzed ortho‐alkoxylation of tertiary benzamides. Using Pd(OAc)₂ as a catalyst and H₂SO₄ as an additive, benzamides with various functional groups underwent the alkoxylation reaction with alcohols efficiently.

中文翻译：

叔丁基甲酰胺的钯催化邻烷氧基化：H2SO4是有效的添加剂

过渡金属催化的CH键烷氧基化反应代表了芳基醚合成的直接有效策略。然而，到目前为止，这些方法的基板范围已经受到很大的限制。在此，我们报道了叔苯甲酰胺的钯催化邻烷氧基化反应。使用Pd（OAc）₂作为催化剂和H ₂ SO ₄作为添加剂，具有各种官能团的苯甲酰胺可以有效地与醇进行烷氧基化反应。

更新日期：2017-11-14

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