Catalytic Hydroalkylation of Allenes,Angewandte Chemie International Edition

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Catalytic Hydroalkylation of Allenes
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2017-11-13 06:17:44 , DOI: 10.1002/anie.201709144
Mitchell Lee ₁ , Mary Nguyen ₁ , Chance Brandt ₁ , Werner Kaminsky ₁ , Gojko Lalic ₁

Affiliation

A catalytic method was developed for the hydroalkylation of allenes using alkyl triflates as electrophiles and silane as a hydride source. The reaction has an excellent substrate scope and is compatible with a wide range of functional groups, including esters, aryl halides, aryl boronic esters, sulfonamides, alkyl tosylates, and alkyl bromides. The reaction mechanism appears to involve unusual dinuclear copper ally complexes as catalytic intermediates.

中文翻译：

丙二烯的催化加氢烷基化

开发了一种催化方法，用于使用烷基三氟甲磺酸酯作为亲电子试剂和硅烷作为氢化物源的丙二烯加氢烷基化。该反应具有优异的底物范围，并且与各种官能团相容，包括酯，芳基卤化物，芳基硼酸酯，磺酰胺，烷基甲苯磺酸盐和烷基溴化物。该反应机理似乎涉及不寻常的双核铜烯丙基配合物作为催化中间体。

更新日期：2017-11-13

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