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A chemiluminescence method for the determination of verapamil hydrochloride in pharmaceutical and environmental samples based on an Fe3O4 nanoparticles enhanced NaHCO3–H2O2 system
Analytical Methods ( IF 2.7 ) Pub Date : 2017-11-13 00:00:00 , DOI: 10.1039/c7ay02164j Mortaza Iranifam 1, 2, 3, 4, 5 , Nasim Rahmati Hendekhale 1, 2, 3, 4, 5
Analytical Methods ( IF 2.7 ) Pub Date : 2017-11-13 00:00:00 , DOI: 10.1039/c7ay02164j Mortaza Iranifam 1, 2, 3, 4, 5 , Nasim Rahmati Hendekhale 1, 2, 3, 4, 5
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In this work, an Fe3O4 nanoparticles (NPs)-enhanced chemiluminescence (CL) method was developed for the determination of verapamil hydrochloride (VRP). To this aim, a quick precipitation method was employed to synthesize Fe3O4 NPs. The synthesised Fe3O4 NPs were then characterized by using techniques including Fourier Transform Infrared (FTIR), X-ray diffraction (XRD) and scanning electron microscopy (SEM). It was found that the Fe3O4 NPs were able to enhance the NaHCO3–H2O2 CL reaction. In addition, it was shown that VRP had an inhibitory effect on the Fe3O4 NPs–NaHCO3–H2O2 system in such a way that the CL intensity was inversely proportional to the concentration of VRP. These findings were used for the establishment of a new, green, simple and sensitive CL analytical method for VRP with a linear dynamic range of 5.0 × 10−6 to 1.0 × 10−3 mol L−1, a correlation coefficient (r2) of 0.99 and a limit of detection of 2.8 × 10−6 mol L−1. The CL method was successfully used for the determination of VRP in pharmaceutical formulations.
中文翻译：
基于Fe 3 O 4纳米颗粒增强的NaHCO 3 -H 2 O 2体系的 化学发光法测定药物和环境样品中的维拉帕米盐酸盐
在这项工作中，开发了一种Fe 3 O 4纳米颗粒（NPs）增强化学发光（CL）方法用于测定盐酸维拉帕米（VRP）的方法。为此，采用快速沉淀法合成了Fe 3 O 4 NP。然后使用包括傅立叶变换红外（FTIR），X射线衍射（XRD）和扫描电子显微镜（SEM）在内的技术对合成的Fe 3 O 4 NP进行表征。发现Fe 3 O 4 NPs能够增强NaHCO 3 –H 2 O 2。CL反应。此外，还表明，VRP对Fe 3 O 4 NPs-NaHCO 3 -H 2 O 2系统具有抑制作用，使得CL强度与VRP浓度成反比。这些发现被用于建立一种新的，绿色的，简单而灵敏的VRP CL分析方法，其线性动态范围为5.0×10 -6至1.0×10 -3 mol L -1，相关系数（r 2）的0.99和检出限2.8×10 -6 mol L -1。CL方法已成功用于药物制剂中VRP的测定。
更新日期：2017-11-13
中文翻译：
基于Fe 3 O 4纳米颗粒增强的NaHCO 3 -H 2 O 2体系的 化学发光法测定药物和环境样品中的维拉帕米盐酸盐
在这项工作中，开发了一种Fe 3 O 4纳米颗粒（NPs）增强化学发光（CL）方法用于测定盐酸维拉帕米（VRP）的方法。为此，采用快速沉淀法合成了Fe 3 O 4 NP。然后使用包括傅立叶变换红外（FTIR），X射线衍射（XRD）和扫描电子显微镜（SEM）在内的技术对合成的Fe 3 O 4 NP进行表征。发现Fe 3 O 4 NPs能够增强NaHCO 3 –H 2 O 2。CL反应。此外，还表明，VRP对Fe 3 O 4 NPs-NaHCO 3 -H 2 O 2系统具有抑制作用，使得CL强度与VRP浓度成反比。这些发现被用于建立一种新的，绿色的，简单而灵敏的VRP CL分析方法，其线性动态范围为5.0×10 -6至1.0×10 -3 mol L -1，相关系数（r 2）的0.99和检出限2.8×10 -6 mol L -1。CL方法已成功用于药物制剂中VRP的测定。
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