In this issue of Cancer Cell, Hurst et al. report an integrated analysis of non-invasive (stage Ta) bladder cancer. Two genomic subtypes are distinguished by chromosome 9q loss, resulting in increased AKT/PI3K/mTOR signaling. Tumors from female patients have a higher frequency of KDM6A mutations.

中文翻译：

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非肌肉浸润性膀胱癌的分子景观。

在本期《癌细胞》中，赫斯特（Hurst）等人。报告了非侵入性（Ta期）膀胱癌的综合分析。两种基因组亚型的特征是染色体9q缺失，导致AKT / PI3K / mTOR信号转导增加。女性患者的肿瘤发生KDM6A突变的频率更高。