The non steroidal anti-inflammatory drugs (NSAID's)-silver(I) metallodrugs of aspirin (aspH), salicylic acid (salH₂), naproxen (napH) acid or p-hydrobenzoic acid (pHbzaH) and the mitochondriotropic triphenylarsine (tpAs) with the formulae [Ag(asp)(tpAs)₃] (1), [Ag(salH)(tpAs)₃] (2), [Ag(nap)(tpAs)₃] (3) and {[Ag(pHbza)(tpAs)₃]∙(dmf)} (4) and [Ag(tpAs)₃(NO₃)] (5) have been synthesized and characterized by m.p., FT-IR, UV-vis and ¹H NMR, spectroscopic techniques and X-ray crystallography.

The in vitro cytotoxic activity of 1–5 against human breast adenocarcinoma cancer cells: MCF-7 (positive to estrogen receptors (ERs)) and MDA-MB-231 (negative to estrogen receptors (ERs)) was evaluated. Compound 4 exhibits the stronger activity against MCF-7 (2.5 ± 0.1 μΜ), while 1 the strongest one against MDA-MB-231 (3.2 ± 0.3 μΜ). The IC₅₀ values against normal human fetal lung fibroblast cells lie between 3.0 and 3.7 μΜ. The toxic effect of 1–5 was evaluated against normal human fetal lung fibroblast cells (MRC-5 cells). The IC₅₀ values of 1–5 lie between 2.9 and 3.7 μΜ. The genotoxicity or not of 1–5 against MRC-5 cells was detected from the presence or absence of micronucleus using fluorescence microscopy. The presence of micronucleus in MRC-5 cells (3.0–3.7% in contrast to 1% of the untreated cells) confirms the in vitro toxic behaviour of the compounds. The apoptotic pathway, though the mitochondrion, was confirmed by cell cycle arrest (increasing of the apoptotic cells, in sub-G₁ phase (3.5 (5) - 13.3% (4)) in contrast of 1.8% in the control group) and permeabilization of the mitochondrial membrane test (MMP assay). Moreover, the ability of 1–5 to interact with Calf Thymus (CT)-DNA was also studied. Compound 4 exhibits the highest DNA binding constant (K_b= (25.0 ± 9.7) × 10⁴ M⁻¹). The inhibitory activity of 1–5 against the enzyme lipoxygenase (LOX) is also investigated. The activity order is 1 > 4 > 3 > 2,5.

非甾体类抗炎药（NSAID）-阿司匹林（aspH），水杨酸（salH ₂），萘普生（napH）酸或对氢苯甲酸（pHbzaH）和线粒体三苯甲lo（tpAs）的银（I）金属药物公式[Ag（asp）（tpAs）₃ ]（1），[Ag（salH）（tpAs）₃ ]（2），[Ag（nap）（tpAs）₃ ]（3）和{[Ag（pHbza） （tpAs）₃ ]∙（dmf）}（4）和[Ag（tpAs）₃（NO ₃）]（5）已合成并通过mp，FT-IR，UV-vis和¹表征。1 H NMR，光谱技术和X射线晶体学。

在体外的细胞毒活性1 - 5针对人乳腺腺癌的癌细胞：MCF-7（阳性雌激素受体（ERS））和MDA-MB-231（阴性雌激素受体（ERS））进行评价。化合物4对MCF-7表现出更强的活性（2.5±0.1μM），而化合物1对MDA-MB-231表现出最强的活性（3.2±0.3μM）。针对正常人胎儿肺成纤维细胞的IC ₅₀值在3.0至3.7μM之间。的毒性效应1 - 5是针对在正常的人胎儿肺成纤维细胞（MRC-5细胞）进行评价。该IC ₅₀的值1 - 5在2.9至3.7μM之间。遗传毒性或没有的1 - 5从存在或不存在使用荧光显微镜微核中检测到针对MRC-5细胞。MRC-5细胞中存在微核（3.0-3.7％，而未处理的细胞为1％）证实了化合物的体外毒性行为。尽管通过线粒体，凋亡途径还是通过细胞周期停滞（在亚G ₁期（3.5（5）-13.3％（4））中凋亡细胞的增加而证实，而对照组为1.8％）和线粒体膜测试的通透性（MMP分析）。而且，能力为1 – 5与小牛胸腺（CT）-DNA相互作用的研究。化合物4表现出最高的DNA结合常数（K _b＝（25.0±9.7）×10 ⁴  M ^-1）。的抑制活性1 - 5针对酶脂氧合酶（LOX）还研究。活动顺序为1  >  4  >  3  >  2,5。