Alkaloids are well-studied secondary metabolites, with recent preclinical studies evidencing that many of them exhibit anti-cancer, anti-depressant, anti-nociceptive, anti-inflammatory, anti-pyretic, anti-platelet, anti-oxidant, and anti-bacterial properties. Aconitum is a genus rich of diverse alkaloids. More than 450 alkaloids have been identified in a variety of species. Songorine is a C₂₀ diterpenoid alkaloid and 12-keto analog of napelline, isolated from Aconitum soongaricum and was associated with a heterogeneous panel of biological functions. However, the bioactivity profile of this natural product has not been reviewed up to now. The present manuscript aims to summarize the most important biological activities associated with songorine administration in preclinical models. The most significant data found in the scientific literature were evaluated in order to summarize the potential clinical utility of songorine in a diverse spectrum of pathologies and conditions. Songorine and its derivatives have many pharmacological effects including anti-arrhythmic, anti-cardiac-fibrillation, excitation of synaptic transmission, anxiolytic effects, anti-nociceptive, anti-inflammatory, anti-arthritis effects, and a regenerative effect in a skin excision wound animal model. Despite its outstanding pharmacotherapeutic potential, songorine has never been tested in clinical trials. Therefore, further evaluation is required to better evaluate its clinical utility.

生物碱是经过充分研究的次级代谢产物，最近的临床前研究表明，其中许多生物碱具有抗癌，抗抑郁，抗伤害性，抗炎，抗退热，抗血小板，抗氧化和抗菌的作用。特性。乌头属是富含多种生物碱的属。在各种物种中已鉴定出450多种生物碱。Songorine是一种C ₂₀二萜生物碱和萘醚的12-酮类似物，从乌头乌头中分离出来。并与生物功能的异质性面板相关。但是，该天然产物的生物活性概况到目前为止尚未得到审查。本手稿旨在总结临床前模型中与Songorine给药相关的最重要的生物学活动。对科学文献中发现的最重要的数据进行了评估，以总结松果碱在各种病理和状况中的潜在临床效用。Songorine及其衍生物在皮肤切除伤口动物中具有许多药理作用，包括抗心律不齐，抗心纤颤，激发突触传递，抗焦虑作用，抗伤害性，抗炎，抗关节炎作用以及再生作用。模型。尽管具有出色的药物治疗潜力，Songorine从未在临床试验中进行过测试。因此，需要进一步评估以更好地评估其临床实用性。