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Synthesis and properties of microenvironment-sensitive oligonucleotides containing a small fluorophore, 3-aminobenzonitrile or 3-aminobenzoic acid
Tetrahedron ( IF 2.1 ) Pub Date : 2017-11-11 , DOI: 10.1016/j.tet.2017.10.062 Hiroaki Ozaki , Takeshi Kawai , Masayasu Kuwahara
中文翻译:
含有小荧光团,3-氨基苄腈或3-氨基苯甲酸的微环境敏感寡核苷酸的合成与性质
更新日期:2017-11-11
Tetrahedron ( IF 2.1 ) Pub Date : 2017-11-11 , DOI: 10.1016/j.tet.2017.10.062 Hiroaki Ozaki , Takeshi Kawai , Masayasu Kuwahara
Two C-nucleosides bearing small fluorescent groups as a base were synthesized by Heck-type coupling reaction and incorporated into DNA. They exhibited environment-sensitive fluorescence and opposite solvatochromic properties. The modified DNAs containing 3-aminobenzonitrile or 3-aminobenzoic acid retained the duplexes and their fluorescence reflected the microenvironment.
中文翻译:
含有小荧光团,3-氨基苄腈或3-氨基苯甲酸的微环境敏感寡核苷酸的合成与性质
通过Heck型偶联反应合成了两个带有小的荧光基团的C-核苷,并掺入了DNA中。它们表现出对环境敏感的荧光和相反的溶剂变色性质。含有3-氨基苄腈或3-氨基苯甲酸的修饰DNA保留了双链体,其荧光反映了微环境。