当前位置: X-MOL 学术Tetrahedron Lett. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Base-promoted formal [4 + 1+1] annulation of aldehyde, N-benzyl amidine and DMSO toward 2,4,6-triaryl pyrimidines
Tetrahedron Letters ( IF 1.5 ) Pub Date : 2017-11-11 , DOI: 10.1016/j.tetlet.2017.11.020
Jin Yuan , Jingbo Li , Bingbing Wang , Song Sun , Jiang Cheng

A base-promoted formal [4 + 1+1] annulation of aldehyde, N-benzyl amidine and DMSO was developed, leading to a series of 2,4,6-triaryl pyrimidines in moderate to good yields. Notably, DMSO served as a methine source, which was activated by base rather than either Lewis acid or electrophile. Molecular O2 was the sole eco-friendly oxidant during this procedure.



中文翻译:

碱促进的醛,N-苄基am和DMSO对[2,4,6-三芳基]嘧啶的正[4 + 1 + 1]环化反应

开发了碱促进的醛,N-苄基am和DMSO的正式[4 + 1 + 1]环状,导致一系列2,4,6-三芳基嘧啶的中度到良好收率。明显地,DMSO用作次甲基源,其被碱而不是路易斯酸或亲电试剂活化。在此过程中,分子O 2是唯一的环保氧化剂。

更新日期:2017-11-11
down
wechat
bug