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Catalytic α-Arylation of Ketones with Heteroaromatic Esters
Synlett ( IF 1.7 ) Pub Date : 2017-10-23 , DOI: 10.1055/s-0036-1589120
Junichiro Yamaguchi 1 , Ryota Isshiki 1 , Ryosuke Takise 2 , Kenichiro Itami 2, 3 , Kei Muto 1
Affiliation  

Heteroaromatic esters were found to be applicable as an arylating agent for the Pd-catalyzed α-arylation of ketones in a decarbonylative fashion. The use of our in-house ligand, dcypt, enabled this unique bond formation. Considering the ubiquity and low cost of ­aromatic esters, the present work will allow for rapid access to valuable α-aryl carbonyl compounds.

中文翻译:

酮与杂芳族酯的催化 α-芳基化

发现杂芳族酯可用作芳基化剂,用于 Pd 催化的酮以脱羰方式进行 α-芳基化。使用我们的内部配体 dcypt 实现了这种独特的键形成。考虑到芳香酯的普遍性和低成本,目前的工作将允许快速获得有价值的 α-芳基羰基化合物。
更新日期:2017-10-23
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