A highly selective and easily handled monoalkylation of primary amide derivatives by using trialkyl phosphates as alkylating reagents in cyclopentyl methyl ether (CPME) was developed. Various monoalkylated amide derivatives were efficiently synthesized by changing the alkyl moiety (e.g., methyl, ethyl, butyl, or benzyl) of the trialkyl phosphate. These phosphate reagents are relatively stable and easily available, and CPME is a useful solvent in process chemistry.

中文翻译：

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酰胺衍生物与磷酸三烷基酯的选择性 N-单烷基化

通过使用磷酸三烷基酯作为环戊基甲基醚 (CPME) 中的烷基化试剂，开发了一种高选择性且易于处理的伯酰胺衍生物的单烷基化。通过改变磷酸三烷基酯的烷基部分（例如甲基、乙基、丁基或苄基），可以有效地合成各种单烷基化酰胺衍生物。这些磷酸盐试剂相对稳定且易于获得，CPME 是过程化学中的有用溶剂。