A S 8 -mediated directed decarboxylative redox-cyclization strategy for the synthesis of 2-substituted benzothiazoles from o -iodoanilines, arylacetic acids, and elemental sulfur catalyzed by cheap copper metal has been developed. This reaction is operationally simple, ligand-free, compatible with a wide range of functional groups, and provides the desired products in good to excellent yields. In addition, a gram-scale experiment was carried out to furnish PMX 610, an antitumor drug.

中文翻译：

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元素硫介导的脱羧氧化还原环化反应：铜催化合成 2-取代苯并噻唑

已经开发出 AS 8 介导的定向脱羧氧化还原环化策略，用于在廉价的铜金属催化下从邻碘苯胺、芳基乙酸和元素硫合成 2-取代苯并噻唑。该反应操作简单，无配体，与多种官能团相容，并以良好到极好的收率提供所需的产物。此外，还进行了克级实验以提供抗肿瘤药物 PMX 610。