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PIP-ing Lipids on Membranes: PTEN Takes the Cake
Molecular Cell ( IF 14.5 ) Pub Date : 2017-11-02 , DOI: 10.1016/j.molcel.2017.10.026
Archna Ravi , Brooke M. Emerling

In this issue of Molecular Cell, Malek et al. (2017) describe a novel HPLC-MS method permitting separation of PI(3,4)P2 and PI(4,5)P2, a technical issue hindering the phosphoinositide signaling field. They use this method to uncover a new target and critical role for PTEN in cancer.



中文翻译:

膜上的PIP-ing脂质:PTEN胜任

在本期《分子细胞》中,Malek等人。(2017)描述了一种新型的HPLC-MS方法,该方法可分离PI(3,4)P 2和PI(4,5)P 2,这是一个阻碍磷酸肌醇信号传导领域的技术问题。他们使用这种方法来发现PTEN在癌症中的新靶标和关键作用。

更新日期:2017-11-02
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