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Trick or TREAT: A Scary-Good New Approach for Single-Molecule mRNA Decay Analysis
Molecular Cell ( IF 14.5 ) Pub Date : 2017-11-02 , DOI: 10.1016/j.molcel.2017.10.027 Joseph Russo , Jeffrey Wilusz
中文翻译:
捣蛋:一种可怕的好方法,用于单分子mRNA衰变分析
更新日期:2017-11-02
Molecular Cell ( IF 14.5 ) Pub Date : 2017-11-02 , DOI: 10.1016/j.molcel.2017.10.027 Joseph Russo , Jeffrey Wilusz
In this issue of Molecular Cell, Horvathova et al. (2017) have developed a powerful approach to single-molecule assessment of RNA decay in living cells by exploiting the ability of flavivirus RNA structural elements to trap XRN1 decay intermediates in dual-labeled reporter constructs.
中文翻译:
捣蛋:一种可怕的好方法,用于单分子mRNA衰变分析
在此期《分子细胞》中,Horvathova等人。(2017)已开发出一种强大的方法,通过利用黄病毒RNA结构元件捕获双标记记者构建体中的XRN1衰变中间体的能力,对活细胞中RNA衰变进行单分子评估。