Pyruvate dehydrogenase (PDH) plays a well-known metabolic role inside cells. In this issue of Cell Host & Microbe, Grayczyk et al. (2017) show that the bacterial pathogen Staphylococcus aureus unexpectedly secretes and repurposes the lipoylated E2 subunit of PDH to suppress TLR-mediated activation of host macrophages by bacterial lipoproteins.

中文翻译：

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Lipoyl-E2-PDH获得第二份工作

丙酮酸脱氢酶（PDH）在细胞内部起着众所周知的代谢作用。在本期《细胞宿主与微生物》中，Grayczyk等人。（2017）显示细菌病原体金黄色葡萄球菌意外分泌并重新利用了PDH的脂化E2亚基来抑制细菌脂蛋白介导的TLR介导的宿主巨噬细胞活化。