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Synthesis of new 1-benzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities
European Journal of Medicinal Chemistry ( IF 6.0 ) Pub Date : 2017-11-10 , DOI: 10.1016/j.ejmech.2017.11.025
Noor-ul-Amin Mohsin , Werner Seebacher , Johanna Faist , Patrick Hochegger , Marcel Kaiser , Pascal Mäser , Ferdinand Belaj , Robert Saf , Nadine Kretschmer , Muaaz Alajlani , Ivana Turek , Adelheid Brantner , Rudolf Bauer , Franz Bucar , Robert Weis

A series of N-benzyl tetrahydropiperidinylidene pyrrolidinium salts have been synthesized and investigated for their antiplasmodial and antitrypanosomal activities as well as for their cytotoxic effects. The antibacterial, antimycobacterial and anticancer potencies of selected compounds were examined, too. Physicochemical parameters were calculated and structure-activity-relationships are discussed.



中文翻译:

新的1-苄基四氢吡啶并亚铵盐的合成及其抗菌和抗细胞活性

已经合成了一系列的N-苄基四氢哌啶亚基吡咯烷鎓盐,并研究了它们的抗血浆和抗锥虫活性以及它们的细胞毒性作用。还检查了所选化合物的抗菌,抗分枝杆菌和抗癌效力。计算了理化参数并讨论了结构-活性-关系。

更新日期:2017-11-10
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