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Atranones with enhancement neurite outgrowth capacities from the crinoid-derived fungus stachybotrys chartarum 952
Tetrahedron ( IF 2.1 ) Pub Date : 2017-11-06 , DOI: 10.1016/j.tet.2017.11.006 Yong-Fang Li , Pan-Pan Zhang , Su-Jun Yan , Jia-Yi Xu , Shah-Iram Niaz , Raza Chand , Chi Him Eddie Ma , Yong-Cheng Lin , Jing Li , Lan Liu
中文翻译:
从海百合衍生的真菌茎线虫Chartarum 952具有增强的神经突向外生长能力的Atranones
更新日期:2017-11-06
Tetrahedron ( IF 2.1 ) Pub Date : 2017-11-06 , DOI: 10.1016/j.tet.2017.11.006 Yong-Fang Li , Pan-Pan Zhang , Su-Jun Yan , Jia-Yi Xu , Shah-Iram Niaz , Raza Chand , Chi Him Eddie Ma , Yong-Cheng Lin , Jing Li , Lan Liu
Seven new atranones (1–5, 7, 10) and three known analogues (6, 8, 9) were isolated from the marine crinoid-derived toxigenic fungus Stachybotrys chartarum 952. The structures of these compounds were elucidated by spectroscopic analysis as well as X-ray crystallographic analysis and electronic circular dichroism calculations. The absolute configurations of three known compounds 6, 8, 9 were first determined. Compound 8 promoted neurite outgrowth from adult DRG neurons significantly without affecting cell survival at 1 μg/mL concentrations.
中文翻译:
从海百合衍生的真菌茎线虫Chartarum 952具有增强的神经突向外生长能力的Atranones
七个新atranones(1-5,7,10)和三个已知类似物(6,8,9)从海洋海百合衍生的毒素的真菌分离纸葡萄穗霉952这些化合物的结构经光谱分析以及阐明X射线晶体学分析和电子圆二色性计算。三种已知的化合物的绝对构6,8,9被首先确定。化合物8推动从成年DRG神经元神经突向外生长显著而不会在1影响细胞存活 μ克/毫升的浓度。