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Absolute configurations of griseorhodins A and C
Tetrahedron Letters ( IF 1.5 ) Pub Date : 2017-11-07 , DOI: 10.1016/j.tetlet.2017.11.008
Humberto E. Ortega , João M. Batista , Weilan G.P. Melo , Jon Clardy , Mônica T. Pupo

The known antibiotic and cytotoxic compounds griseorhodin A (1) and griseorhodin C (2) were produced in solid culture by Streptomyces puniceus AB10, which was isolated from the leaf-cutter ant Acromyrmex rugosus rugosus. Their absolute configurations were unambiguously established as 6S,6aR,7S,8S and 6R,6aR,7S,8R, respectively, using vibrational circular dichroism (VCD) and density functional theory (DFT) calculations.



中文翻译:

灰黄霉素A和C的绝对构型

已知的抗生素和细胞毒性化合物灰藻糖蛋白A(1)和灰藻糖蛋白C(2)是由刺槐链霉菌AB10固态培养产生的,该菌是从切叶蚁Acromyrmex rugosus rugosus中分离得到的。利用振动圆二色性(VCD)和密度泛函理论(DFT)计算,将它们的绝对构型明确确定为6 S,6a R,7 S,8 S和6 R,6a R,7 S,8 R。

更新日期:2017-11-07
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