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Synthesis of N-alkoxy-substituted 2H-benzimidazoles
Tetrahedron Letters ( IF 1.5 ) Pub Date : 2017-11-06 , DOI: 10.1016/j.tetlet.2017.11.007
Nurul H. Ansari , Björn C.G. Söderberg

Treatment of 2-nitro-N-(2-methyl-1-propen-1-yl)benzenamines with potassium tert-butoxide in tert-butanol followed by the addition of an electrophile affords N-alkoxy-2H-benzimidazoles. Electrophiles including methyl iodide, allylic bromides, propargylic bromides, benzyl bromide, and acetyl chloride gave good to excellent yields of product while 1-iodo- and 2-iodo-butane afforded very low yields.



中文翻译:

N-烷氧基取代的2 H-苯并咪唑的合成

的2-硝基治疗ñ - (2-甲基-1-丙烯-1-基)benzenamines钾丁醇在丁醇,接着添加亲电子试剂,得到的ñ -烷氧基-2- ħ -benzimidazoles。包括甲基碘,烯丙基溴,炔丙基溴,苄基溴和乙酰氯在内的亲电试剂的收率非常好,而1-碘-和2-碘-丁烷的收率却非常低。

更新日期:2017-11-06
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