A major challenge to patients, clinicians, family members, and scientists is the unpredictable future that accompanies a diagnosis of Parkinson's disease. When met with the question “what does my future hold?” it is difficult to give predictions that are likely to be useful to the patient. Some individuals will face features that rapidly and adversely affect their quality of life; others will experience a prolonged and fairly benign course, initially well managed by drugs and lifestyle changes. Variability between patients in core features of this multisystem disease—eg, motor decline, neuropsychiatric changes, mood disorders, dysautonomic signs, and fatigue—is the rule.

中文翻译：

---

预测帕金森氏病患者的病情进展

对患者，临床医生，家庭成员和科学家的主要挑战是伴随着帕金森氏病诊断的不可预测的未来。当遇到“我的未来会怎样吗？”的问题时 很难给出可能对患者有用的预测。有些人将面临迅速而不利地影响其生活质量的特征；其他人则将经历一个漫长而公平的过程，最初是通过药物和生活方式的改变来很好地进行管理的。通常，患者之间在这种多系统疾病的核心特征中的变异性（例如运动能力下降，神经精神病学变化，情绪障碍，自主神经功能异常和疲劳）。