Structures of the Largest Amphidinol Homologues from the Dinoflagellate Amphidinium carterae and Structure–Activity Relationships,Journal of Natural Products

当前位置： X-MOL 学术 › J. Nat. Prod. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Structures of the Largest Amphidinol Homologues from the Dinoflagellate Amphidinium carterae and Structure–Activity Relationships
Journal of Natural Products ( IF 3.3 ) Pub Date : 2017-11-09 00:00:00 , DOI: 10.1021/acs.jnatprod.7b00345
Masayuki Satake ₁ , Kimberly Cornelio _{2,

3} , Shinya Hanashima ₂ , Raymond Malabed ₂ , Michio Murata _{2,

3} , Nobuaki Matsumori ₄ , Huiping Zhang ₅ , Fumiaki Hayashi ₅ , Shoko Mori ₆ , Jong Souk Kim ₇ , Chang-Hoon Kim ₇ , Jong-Soo Lee ₈

Affiliation

Amphidinols are polyketide metabolites produced by marine dinoflagellates and are chiefly composed of a long linear chain with polyol groups and polyolefins. Two new homologues, amphidinols 20 (AM20, 1) and 21 (AM21, 2), were isolated from Amphidinium carterae collected in Korea. Their structures were elucidated by detailed NMR analyses as amphidinol 6-type compounds with remarkably long polyol chains. Amphidinol 21 (2) has the longest linear structure among the amphidinol homologues reported so far. The congeners, particularly amphidinol 21 (2), showed weaker activity in hemolysis and antifungal assays compared to known amphidinols.

中文翻译：

鞭毛双歧杆菌最大的两栖动物同系物的结构及其构效关系

两性酚是由海洋鞭毛藻产生的聚酮化合物，主要由带有多元醇基团和聚烯烃的长直链组成。两个新的同系物，amphidinols 20（AM20，1）和21（AM21，2），从分离前沟carterae收集在韩国。通过详细的NMR分析，阐明了其结构为具有明显长的多元醇链的两性酚6型化合物。在迄今报道的两性酚同系物中，两性酚21（2）具有最长的线性结构。与已知的两性酚相比，同类物，尤其是两性酚21（2）在溶血和抗真菌试验中显示出较弱的活性。

更新日期：2017-11-09

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11