TWIK-related acid-sensitive potassium channel 1 (TASK-1 encoded by KCNK3) belongs to the family of two-pore domain potassium channels. This gene subfamily is constitutively active at physiological resting membrane potentials in excitable cells, including smooth muscle cells, and has been particularly linked to the human pulmonary circulation. TASK-1 channels are sensitive to a wide array of physiological and pharmacological mediators that affect their activity such as unsaturated fatty acids, extracellular pH, hypoxia, anaesthetics and intracellular signalling pathways. Recent studies show that modulation of TASK-1 channels, either directly or indirectly by targeting their regulatory mechanisms, has the potential to control pulmonary arterial tone in humans. Furthermore, mutations in KCNK3 have been identified as a rare cause of both familial and idiopathic pulmonary arterial hypertension. This review summarises our current state of knowledge of the functional role of TASK-1 channels in the pulmonary circulation in health and disease, with special emphasis on current advancements in the field. Current advancements of TASK-1/KCNK3 channels in the human pulmonary circulation in health and disease http://ow.ly/xgJo30fNZRN

中文翻译：

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肺中的 TASK-1 (KCNK3) 通道：从细胞生物学到临床意义

TWIK 相关的酸敏感钾通道 1（由 KCNK3 编码的 TASK-1）属于双孔域钾通道家族。该基因亚家族在可兴奋细胞（包括平滑肌细胞）的生理静息膜电位下具有组成型活性，并且与人类肺循环特别相关。TASK-1 通道对影响其活性的多种生理和药理介质敏感，例如不饱和脂肪酸、细胞外 pH、缺氧、麻醉剂和细胞内信号通路。最近的研究表明，直接或间接通过靶向调节机制对 TASK-1 通道进行调节，有可能控制人类的肺动脉张力。此外，KCNK3 突变已被确定为家族性和特发性肺动脉高压的罕见原因。本综述总结了我们目前对 TASK-1 通道在健康和疾病肺循环中的功能作用的认识，特别强调了该领域的当前进展。TASK-1/KCNK3 通道在健康和疾病中人类肺循环的最新进展 http://ow.ly/xgJo30fNZRN