Water-soluble and UV traceable isatoic anhydride-based reagents for bioconjugation,Organic & Biomolecular Chemistry

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Water-soluble and UV traceable isatoic anhydride-based reagents for bioconjugation
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2017-11-06 00:00:00 , DOI: 10.1039/c7ob02377d
Adam Fessler _{1,

2,

3,

4} , Corey Garmon _{1,

2,

3,

4} , Thomas Heavey _{1,

2,

3,

4} , Anthony Fowler _{1,

2,

3,

4} , Craig Ogle _{1,

2,

3,

4}

Affiliation

Isatoic anhydride is elaborated to water soluble bioconjugation reagents that gives functionality and water solubility in one self-cleaning step. This new platform offers high atom economy with carbon dioxide being the only byproduct, and is shown to very quickly and efficiently label proteins in bicarbonate buffered solutions.

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