A conceptually new synthetic approach that provides general access to the aspidosperma alkaloids (+)-aspidospermidine and (−)-tabersonine was developed. This method is based on the regioselective indolization of an ene–hydrazide, which was obtained via a base-catalyzed intramolecular aza-Michael reaction, in situ trapping of the resulting enolate, and subsequent C–N coupling with phenyl hydrazide.

中文翻译：

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定向费歇尔吲哚化作为（+）-天冬酰胺和（-）-塔布罗宁的总合成方法

开发了一种概念上新颖的合成方法，该方法可提供对蛇形精子生物碱（+）-aspidospermidine和（-）-tabersonine的一般使用途径。该方法基于烯-酰肼的区域选择性吲哚化，这是通过碱催化的分子内氮杂-Michael反应，原位捕获所得的烯醇化物以及随后的CN–N与酰肼的偶联而获得的。