The Center for Arrhythmia Research (CAR) and the Michigan Biology of Cardiovascular Aging (MBoCA) program at the University of Michigan (UM) are performing synergistic research to examine how aging impacts arrhythmias, in particular atrial fibrillation (AF). This collaborative research endeavor has been driven by a very clear increasing clinical demand posed by the aging of our society. Specifically, by the year 2050, the number of older people over 65 years of age will exceed the number of younger people for the first time in history. Given this important trend, the growing healthcare needs of the aging population exacerbated by cardiovascular diseases will pose an ever-increasing burden on our healthcare resources. Cardiovascular diseases in the aging population have well surpassed other age-associated diseases such as susceptibility to infection, chronic lung disease, and cancer as a cause of morbidity and mortality.1 Investigation into the field of aging and cardiovascular diseases has tremendous potential to impact the health and quality of life of older people as no therapies exist that explicitly target aging-specific processes that enhance cardiovascular diseases such as AF. Advanced age is the most critical factor for the development of AF; 10% of patients in their eighth decade have AF and 50% of patients with AF are 80 years of age or older. AF is largely a geriatric condition, and older patients with AF have associated mortality and morbidity not only because of hemodynamic effects and thromboembolism but also because of side effects of therapy including an increased propensity for bleeding with anticoagulation and falls from heart rate–controlling medications.2 Not only does AF in older people pose a large healthcare morbidity and mortality burden, but AF with aging is costly. Thus, research is urgently needed to understand how aging predisposes to AF. The UM CAR (http://www.med.umich.edu/arrhythmia_research/) is a multidisciplinary …

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心律失常研究中心与密歇根大学心血管衰老的密歇根生物学之间的协同研究

密歇根大学（UM）的心律失常研究中心（CAR）和密歇根大学的心血管衰老生物学（MBoCA）计划正在进行协同研究，以检查衰老如何影响心律不齐，尤其是房颤（AF）。这项合作研究的努力是由我们的社会老龄化带来的非常明显的临床需求增长驱动的。具体而言，到2050年，65岁以上的老年人口将有史以来首次超过年轻人口。鉴于这一重要趋势，心血管疾病加剧的人口老龄化对医疗保健的需求不断增长，将给我们的医疗保健资源带来越来越大的负担。人口老龄化中的心血管疾病已远远超过其他与年龄有关的疾病，如易感染性，慢性肺部疾病和致病性和死亡率的癌症。1对衰老和心血管疾病领域的研究具有巨大的潜力，可能会影响到老年人的心血管疾病。老年人的健康和生活质量，因为不存在明确针对衰老的过程来增强心血管疾病（例如AF）的疗法。高龄是房颤发展的最关键因素。在他们的第八个十年中，有10％的患者患有房颤，而50％的房颤患者年龄在80岁以上。AF在很大程度上是老年病，老年房颤患者的死亡率和发病率不仅与血流动力学效应和血栓栓塞有关，而且还归因于治疗的副作用，包括抗凝性出血的倾向增加以及心律控制药物的下降。2老年房颤不仅如此人们对医疗保健的发病率和死亡率构成沉重负担，但随着年龄增长而进行房颤的代价高昂。因此，迫切需要进行研究以了解衰老如何导致房颤。UM CAR（http://www.med.umich.edu/arrhythmia_research/）是一个多学科的…… 迫切需要进行研究，以了解衰老是导致房颤的原因。UM CAR（http://www.med.umich.edu/arrhythmia_research/）是一个多学科的…… 迫切需要进行研究，以了解衰老是导致房颤的原因。UM CAR（http://www.med.umich.edu/arrhythmia_research/）是一个多学科的……