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An Erysipeloid Cutaneous Eruption in a Woman With Advanced Breast Cancer
JAMA Oncology ( IF 22.5 ) Pub Date : 2017-11-01 , DOI: 10.1001/jamaoncol.2017.2325
Christina E. Alexander 1 , Melody Maarouf 1 , Drew J. B. Kurtzman 1
Affiliation  

A woman in her 60s presented with a 3-month history of a progressive, asymptomatic cutaneous eruption on her chest and back. She had a complex history of breast cancer on the left side that was first diagnosed in 1991 and was treated with lumpectomy, radiotherapy, cyclophosphamide, methotrexate, and fluorouracil. In 2001, she experienced local disease recurrence and underwent complete mastectomy with axillary lymph node dissection on the left side and received adjuvant treatment with tamoxifen citrate and anastrozole. In 2014, she developed axillary lymphadenopathy on the right side and was found to have metastatic disease. She subsequently underwent axillary lymph node dissection on the right side, followed by treatment with doxorubicin hydrochloride and cyclophosphamide. Her most recent mammogram and positron-emission tomography–computed tomography (PET/CT) showed no evidence of active disease. At the time of her evaluation, the patient’s physical examination was remarkable for discrete erysipeloid plaques on her chest, back, and right shoulder (Figure 1A). The lesions were warm and indurated but nontender to palpation. Serum chemistry profile, complete blood cell counts, and hepatic and renal function testing had normal results. Lesional skin biopsies were performed (Figure 1B).



中文翻译:

患有晚期乳腺癌的女性中的类胶质皮肤爆发。

一名60多岁的妇女在胸部和背部出现了3个月的进行性无症状皮肤喷发病史。她的左侧患有复杂的乳腺癌史,于1991年首次被诊断出,并接受了肿块切除术,放疗,环磷酰胺,甲氨蝶呤和氟尿嘧啶治疗。在2001年,她经历了局部疾病的复发,并接受了左侧乳房腋窝淋巴结清扫术的完全乳房切除术,并接受了柠檬酸他莫昔芬和阿那曲唑的辅助治疗。2014年,她在右侧发生腋窝淋巴结肿大,被发现患有转移性疾病。随后,她在右侧进行了腋窝淋巴结清扫术,随后接受盐酸阿霉素和环磷酰胺治疗。她最近的乳房X线照片和正电子发射断层扫描计算机断层扫描(PET / CT)均未发现活动性疾病的证据。在进行评估时,患者的身体检查对于胸部,背部和右肩上的离散的类红斑斑而言非常出色(图1A)。病变温暖而硬结,但不触诊。血清化学成分,全血细胞计数以及肝肾功能检查均正常。进行了病灶皮肤活检(图1B)。肝肾功能检查结果正常。进行了病灶皮肤活检(图1B)。肝肾功能检查结果正常。进行了病灶皮肤活检(图1B)。

更新日期:2017-11-10
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