To the Editor The study by Han and collaborators¹ provides important data on genital human papillomavirus (HPV) infection, on a national level. There is a serious knowledge gap about HPV infection in males compared with females. The data presented in the article highlight that 1 in 4 men aged 18 to 59 years harbors a cancer-causing HPV type, thus serving as an important reservoir for oncogenic HPV infection. The risk of HPV-induced cancer of the penis is low, with the Centers for Disease Control and Prevention (CDC) reporting 1168 new cases a year.² This suggests that while HPV infection in males is common, most cases do not progress to cancer. This is not the case for cervical HPV infection in females, as 10% of infected women will progress to a high-grade cervical lesion within 2 years.³

致编辑Han 及其合作者¹的研究提供了国家层面上生殖器人乳头瘤病毒 (HPV) 感染的重要数据。与女性相比，男性对 HPV 感染的认识存在严重差距。文章中提供的数据强调，在 18 至 59 岁的男性中，有四分之一的人携带致癌 HPV 类型，因此是致癌 HPV 感染的重要宿主。HPV 诱发的阴茎癌的风险很低，疾病控制和预防中心 (CDC) 每年报告 1168 例新病例。²这表明虽然男性 HPV 感染很常见，但大多数病例不会发展为癌症。女性宫颈 HPV 感染并非如此，因为 10% 的感染女性会在 2 年内进展为高级别宫颈病变。³