Regioselective three-component synthesis of 2,3-disubstituted quinolines via the enaminone modified Povarov reaction,Organic & Biomolecular Chemistry

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Regioselective three-component synthesis of 2,3-disubstituted quinolines via the enaminone modified Povarov reaction
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2017-10-31 00:00:00 , DOI: 10.1039/c7ob02411h
Yi Li _{1,

2,

3,

4} , Xiaoji Cao _{5,

6,

7,

8} , Yunyun Liu _{1,

2,

3,

4} , Jie-Ping Wan _{1,

2,

3,

4}

Affiliation

The regioselective construction of functionalized quinolines by the three-component reactions of enaminones, aldehydes and anilines is accomplished. Unlike conventional Povarov reactions employing terminal alkynes or alkenes as C3–C4 fragment sources which provide 2,4-disubstituted quinolines, the present method allows fast and regioselective formation of 2,3-disubstituted quinolines as a modified new version of the Povarov reaction.

中文翻译：

通过烯胺酮修饰的Povarov反应的区域选择性三组分合成2,3-二取代的喹啉

通过烯胺酮，醛和苯胺的三组分反应实现了功能化喹啉的区域选择性构建。与常规的Povarov反应不同，后者采用末端炔烃或烯烃作为C3-C4片段来源，提供2，4-二取代的喹啉，本方法允许快速和区域选择性地形成2,3-二取代的喹啉，作为Povarov反应的改进形式。

更新日期：2017-11-08

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