Organic CO Prodrugs Activated by Endogenous ROS,Organic Letters

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Organic CO Prodrugs Activated by Endogenous ROS
Organic Letters ( IF 4.9 ) Pub Date : 2017-11-07 00:00:00 , DOI: 10.1021/acs.orglett.7b02775
Zhixiang Pan ₁ , Jun Zhang _{1,

2} , Kaili Ji ₁ , Vayou Chittavong ₁ , Xingyue Ji ₁ , Binghe Wang ₁

Affiliation

CO prodrugs with triggered release mechanisms are highly desirable for targeted delivery. Herein described are organic CO prodrugs that are activated by ROS and thus can be used to selectively deliver CO to cells with elevated ROS levels. Such CO prodrugs can serve as powerful tools for targeted delivery to disease sites with elevated ROS levels and to explore the therapeutic applications of CO.

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