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Organic CO Prodrugs Activated by Endogenous ROS
Organic Letters ( IF 4.9 ) Pub Date : 2017-11-07 00:00:00 , DOI: 10.1021/acs.orglett.7b02775
Zhixiang Pan 1 , Jun Zhang 1, 2 , Kaili Ji 1 , Vayou Chittavong 1 , Xingyue Ji 1 , Binghe Wang 1
Affiliation  

CO prodrugs with triggered release mechanisms are highly desirable for targeted delivery. Herein described are organic CO prodrugs that are activated by ROS and thus can be used to selectively deliver CO to cells with elevated ROS levels. Such CO prodrugs can serve as powerful tools for targeted delivery to disease sites with elevated ROS levels and to explore the therapeutic applications of CO.

中文翻译:

内源性ROS活化的有机CO前药

具有触发释放机制的CO前药对于靶向递送是非常需要的。本文描述了被ROS活化的有机CO前药,因此可用于选择性地将CO输送至ROS水平升高的细胞。此类CO前药可作为强大的工具,用于靶向递送至ROS水平升高的疾病部位,并探索CO的治疗应用。
更新日期:2017-11-07
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