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Rhodium-Catalyzed Site-Selective Coupling of Indoles with Diazo Esters: C4-Alkylation versus C2-Annulation
Organic Letters ( IF 4.9 ) Pub Date : 2017-11-07 00:00:00 , DOI: 10.1021/acs.orglett.7b03099
Xiaohong Chen 1, 2 , Guangfan Zheng 1 , Yunyun Li 1 , Guoyong Song 2 , Xingwei Li 1
Affiliation  

A Rh(III)-catalyzed site-selective C–H activation of C(3)-functionalized indoles in a coupling with diazo esters has been realized with carbonyl as a weakly coordinating group. The coupling selectivity is dictated by the temperature and additives, affording either C4-alkylated indoles or C2-annulated lactones in moderate to excellent efficiency.

中文翻译:

铑催化的重氮酯与吲哚吲哚的位点选择性偶联:C4-烷基化与C2-环化

用羰基作为弱配位基团,已经实现了Rh(III)催化的C(3)-官能化的吲哚与重氮酯偶联的位点C–H活化。偶联选择性由温度和添加剂决定,可以中等至极好的效率提供C4烷基化的吲哚或C2环化的内酯。
更新日期:2017-11-07
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