Experimental verification of simultaneous desalting and molecular preconcentration by ion concentration polarization,Lab on a Chip

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Experimental verification of simultaneous desalting and molecular preconcentration by ion concentration polarization
Lab on a Chip ( IF 6.1 ) Pub Date : 2017-09-28 00:00:00 , DOI: 10.1039/c7lc00857k
Wonseok Kim _{1,

2,

3,

4} , Sungmin Park _{1,

2,

3,

4} , Kihong Kim _{1,

2,

3,

4} , Sung Jae Kim _{1,

2,

3,

4,

5}

Affiliation

While the ion concentration polarization (ICP) phenomenon has been intensively researched for the last decade, a complete picture of ion and analyte distributions near nanoporous membranes is strongly desired, not only for fundamental nano-electrokinetic studies but also for the development of lab-on-a-chip applications. Since direct concentration measurements, using either time-consuming collection or microelectrodes, are limited due to low throughput (<nL min⁻¹ in typical micro/nanofluidic device) and Faradaic reactions, respectively, we measured the concentration changes of prefilled solutions in individual reservoirs in this work. As a result, analytes larger than the size of nanopores were completely repelled by the ICP layer, 65% of cations were transported through the nanoporous membrane to sustain the ICP phenomenon, and the remaining anions were consumed by electrode reactions for electro-neutrality requirements. These combined effects would enable the perfect recovery of a target analyte and the removal of unnecessary salts simultaneously. Using this scenario, the novel concept of an ink recycler was also demonstrated in this work. We showed that 40% of unnecessary salt, which causes serious deterioration of inkjet heads, was removed, while the concentration of ink molecules was doubled in a single-step operation. This simultaneous desalting and molecular preconcentration mechanism would be a key operational strategy of various refinery/purification applications for drug discovery and the chemical industry, etc.

中文翻译：

离子浓差极化同时脱盐和分子预富集的实验验证

尽管在过去十年中对离子浓度极化（ICP）现象进行了深入研究，但人们强烈希望获得完整的纳米多孔膜附近的离子和分析物分布图，不仅用于基本的纳米电动学研究，而且还用于实验室开发。单芯片应用程序。由于使用低耗时间的采集（<nL min ^-1，使用耗时的收集或微电极进行直接浓度测量是有限的在典型的微/纳流体装置中）和法拉第反应中，我们在这项工作中测量了各个储层中预填充溶液的浓度变化。结果，大于纳米孔大小的分析物被ICP层完全排斥，65％的阳离子通过纳米多孔膜传输以维持ICP现象，而其余的阴离子则被电极反应消耗，以达到电中性要求。这些综合效果将使目标分析物的完美回收和同时去除不必要的盐分成为可能。使用此方案，在此工作中还演示了墨水回收器的新颖概念。我们证明，去除了40％的不必要的盐，这些盐会导致喷墨头严重损坏，而墨水分子的浓度在一步操作中就增加了一倍。这种同时进行的脱盐和分子预浓缩机制将是各种炼油厂/提纯应用中用于药物发现和化学工业的关键操作策略，ETC。

更新日期：2017-11-07

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