Spontaneous fluctuations in hemodynamic signals in the absence of a task or overt stimulation are used to infer neural activity. We tested this coupling by simultaneously measuring neural activity and changes in cerebral blood volume (CBV) in the somatosensory cortex of awake, head-fixed mice during periods of true rest and during whisker stimulation and volitional whisking. We found that neurovascular coupling was similar across states and that large, spontaneous CBV changes in the absence of sensory input were driven by volitional whisker and body movements. Hemodynamic signals during periods of rest were weakly correlated with neural activity. Spontaneous fluctuations in CBV and vessel diameter persisted when local neural spiking and glutamatergic input were blocked, as well as during blockade of noradrenergic receptors, suggesting a non-neuronal origin for spontaneous CBV fluctuations. Spontaneous hemodynamic signals reflect a combination of behavior, local neural activity, and putatively non-neural processes.

中文翻译：

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静息状态下血液动力学信号与正在进行的神经活动之间的相关性较弱

在没有任务或没有明显刺激的情况下，血流动力学信号的自发性波动可用于推断神经活动。我们通过同时测量神经活动和觉醒的，头枕固定的小鼠的体感皮层的脑血容量（CBV）在真实休息期间以及晶须刺激和自发性搅拌期间的变化来测试这种耦合。我们发现神经血管耦合在各州之间是相似的，并且在没有感觉输入的情况下，较大的，自发的CBV变化是由自愿的晶须和身体运动驱动的。休息期间的血流动力学信号与神经活动弱相关。当局部神经刺激和谷氨酸能输入被阻断以及去甲肾上腺素能受体被阻断时，CBV和血管直径的自发性波动持续存在，提示自发CBV波动的非神经源性。自发的血流动力学信号反映了行为，局部神经活动和假定的非神经过程的组合。